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Skinsseutical Hyaluronic Acid Intensifier Multi-Glycan - hydrating serum
Best Seller
Best Hydrating SerumClinically TestedDermatologist Approved

hydrating serum

Hyaluronic Acid Intensifier Multi-Glycan

Next-Generation Hydration with Multi-Glycan Technology

★★★★★4.81,923 reviews

$120.00

— $4.00 / ml

Only 62 left in stock — ships in 3–5 business days

Hyaluronic Acid Intensifier Multi-Glycan goes beyond surface hydration. This corrective serum amplifies your skin's own hyaluronic acid levels by up to 30% while a proprietary multi-glycan complex supports the skin's natural ability to replenish its moisture reserves. The result: visibly plumper, smoother, more resilient skin that stays hydrated from within — not just coated on top.

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1
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Key Ingredients

Hyaluronic AcidProxylaneMulti-Glycan Complex

Recommended For

normal skindry skincombination skinsensitive skin

What Makes This Hyaluronic Acid Serum Different?

Most hyaluronic acid serums simply apply HA to the skin surface, where it temporarily attracts moisture and plumps the epidermis. While this provides immediate hydration, the effect is transient — it wears off as the product is washed away or absorbed. Hyaluronic Acid Intensifier Multi-Glycan takes a fundamentally different approach.

This serum combines topical multi-weight hyaluronic acid with Proxylane™ — a patented molecule that stimulates the skin's own production of glycosaminoglycans (GAGs), including endogenous hyaluronic acid. Rather than just adding hydration from outside, it helps the skin rebuild its internal moisture reservoirs. The result is deeper, longer-lasting hydration that persists even between applications.

The Multi-Glycan Complex further supports this process by providing a diverse array of sugar-based molecules that act as structural scaffolding for the skin's extracellular matrix. This complex helps maintain the three-dimensional network that keeps skin plump, elastic, and resistant to dehydration-induced fine lines.

30%
Increase in skin's hyaluronic acid levels
1000×
Water-binding capacity of hyaluronic acid
92%
Of users reported visibly plumper skin
24h
Sustained hydration with a single application

Key Ingredients & What Each One Does

Hyaluronic Acid

Multi-weight · Surface + Deep Hydration

A naturally occurring polysaccharide that holds up to 1,000× its weight in water. This formula uses multiple molecular weights: high-weight HA forms a moisture-retaining film on the skin surface, medium-weight HA penetrates the outer epidermis for mid-level plumping, and low-weight HA reaches deeper layers to hydrate from within. Together they provide comprehensive hydration at every skin level.

Proxylane™

Patented · Endogenous HA Stimulation

Derived from beechwood sugar, Proxylane™ stimulates the skin's own production of glycosaminoglycans, including hyaluronic acid, at the dermal-epidermal junction. This is the key differentiator — rather than just adding external HA, Proxylane™ helps the skin produce more of its own. Clinically proven to increase skin's HA content by up to 30%, resulting in improved volume, firmness, and resilience.

Multi-Glycan Complex

Proprietary Blend · Structural Support

A synergistic blend of glycan molecules (complex sugars) that support the extracellular matrix — the structural network between skin cells. Glycans serve as building blocks for GAGs and help maintain the three-dimensional scaffold that keeps skin plump and elastic. By replenishing this matrix, the Multi-Glycan Complex enhances the skin's natural ability to retain moisture and resist dehydration.

How to Use

01

Cleanse

Start with clean skin. Use a gentle cleanser and pat dry. For best absorption, apply the serum while skin is still slightly damp — this gives the hyaluronic acid immediate moisture to bind to.

02

Apply Serum

Dispense 3–5 drops onto fingertips and press into the face, neck, and chest. The lightweight gel-serum texture absorbs rapidly. Focus on areas prone to dehydration: cheeks, under-eyes, and forehead.

03

Layer & Lock

Follow immediately with a moisturizer to seal hydration into the skin. This "sandwich" technique locks the hyaluronic acid in place and prevents it from evaporating — especially important in dry or air-conditioned environments.

04

Use AM + PM

For maximum hydration benefits, use twice daily — morning and evening. In the AM, follow with SPF. In the PM, follow with a richer night cream for overnight moisture replenishment.

Suitable Skin Types

Hyaluronic Acid Intensifier is suitable for virtually all skin types. Its oil-free, lightweight gel texture absorbs without greasiness, making it comfortable for oily and acne-prone skin. The intense hydration benefits are especially valuable for dry, dehydrated, and sensitive skin that struggles to retain moisture.

Normal SkinDry SkinCombination SkinSensitive SkinDehydrated Skin

Skin Concerns It Addresses

This serum targets dehydration-related concerns at their root. By boosting internal hyaluronic acid production rather than just masking dryness on the surface, it addresses the underlying cause of fine lines, dullness, and rough texture associated with moisture loss.

Dryness & DehydrationFine Lines & WrinklesDullnessLoss of PlumpnessRough TextureSensitive Skin

The Science Behind the Formula

Why this specific combination of ingredients produces results that no single ingredient can achieve alone.

Endogenous HA Production

As skin ages, its natural production of hyaluronic acid declines — by age 50, the skin contains roughly half the HA it had at age 20. Proxylane™ addresses this decline at the source by stimulating fibroblasts to produce more glycosaminoglycans. This means the skin is rebuilding its own moisture-retaining molecules rather than relying solely on externally applied HA.

Multi-Weight Penetration

Different molecular weights of hyaluronic acid serve different functions. High-weight HA (>1000 kDa) cannot penetrate the stratum corneum but forms an excellent moisture-retaining film on the surface. Medium-weight HA (50–1000 kDa) penetrates the outer epidermis. Low-weight HA (<50 kDa) can reach deeper layers. This serum uses all three to hydrate comprehensively.

The Glycan Matrix

Glycans are complex sugar molecules that form the backbone of the skin's extracellular matrix. They serve as structural scaffolding, signal molecules for cell communication, and substrates for GAG synthesis. The Multi-Glycan Complex replenishes this matrix, creating a more supportive environment for moisture retention, collagen organization, and overall skin resilience.

Frequently Asked Questions

Everything you need to know — answered directly and in detail.

Most HA serums only apply hyaluronic acid topically, providing temporary surface hydration. This serum goes further:

  • Multi-weight HA hydrates at every skin level, not just the surface.
  • Proxylane™ stimulates the skin to produce its own HA — up to 30% more.
  • Multi-Glycan Complex rebuilds the structural matrix that retains moisture long-term.

The result is deeper, longer-lasting hydration that persists between applications.

Yes — Hyaluronic Acid Intensifier layers beautifully with other actives:

  • AM routine: Vitamin C serum → HA Intensifier → moisturizer → SPF
  • PM routine: Retinol → HA Intensifier → night cream

HA helps buffer potential dryness or irritation from low-pH vitamin C and retinoids.

  • Immediate: Skin feels hydrated, plumper, and smoother right after application.
  • 1–2 weeks: Sustained improvement in skin texture and comfort.
  • 4–8 weeks: Visible improvement in fine lines caused by dehydration, increased radiance and plumpness from Proxylane™ stimulation.

Slightly damp skin is ideal. Hyaluronic acid works by attracting and binding water — applying it to damp skin gives it immediate moisture to grab onto. Follow with moisturizer to seal it in. In very dry or air-conditioned environments, always layer a moisturizer on top to prevent the HA from drawing moisture from deeper skin layers.

Yes. The formula is oil-free, non-comedogenic, and has a lightweight gel texture that absorbs quickly without greasiness. Oily skin still needs hydration — and using a hydrating serum can actually help reduce excess oil production by signaling to the skin that it doesn't need to overcompensate with sebum.

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