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Skinsseutical Hydrating B5 Gel - hydrating serum
Best Seller
Best Lightweight HydratorSensitive Skin ApprovedDermatologist Tested

hydrating serum

Hydrating B5 Gel

Vitamin B5 + Hyaluronic Acid Moisture-Replenishing Gel

★★★★★4.82,345 reviews

$95.00

— $3.17 / ml

Only 81 left in stock — ships in 3–5 business days

Hydrating B5 Gel is an oil-free, lightweight hydrating serum that combines Vitamin B5 (panthenol) with hyaluronic acid to deliver deep, sustained moisture without heaviness or greasiness. Designed for daily use under any skincare routine, it replenishes the skin's natural moisture reserves, soothes irritation, and creates a smooth, plump base for serums, moisturizers, and makeup.

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1
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Key Ingredients

Hyaluronic AcidVitamin B5Glycerin

Recommended For

normal skindry skincombination skinoily skinsensitive skin

Why Vitamin B5 + Hyaluronic Acid Is the Ultimate Hydration Duo

Hydration is the foundation of healthy skin — without adequate moisture, every other skincare product you use becomes less effective. Dehydrated skin appears dull, shows fine lines more prominently, is more prone to irritation, and cannot support the active processes (collagen synthesis, cell turnover, barrier repair) that keep skin looking youthful.

Vitamin B5 (panthenol) is a provitamin that converts to pantothenic acid in the skin — an essential nutrient that plays a central role in cellular energy production, tissue repair, and moisture regulation. It acts as a humectant (drawing moisture from the environment) and an emollient (softening and smoothing the skin surface), while also accelerating the skin's natural wound-healing process.

Combined with multi-weight Hyaluronic Acid and Glycerin, Hydrating B5 Gel creates a comprehensive hydration system: HA attracts and binds water at multiple depths, B5 supports the skin's ability to use and retain that moisture, and Glycerin reinforces the moisture-retaining film on the surface. The result is a gel that feels lightweight on application but delivers serious, lasting hydration.

B5
Vitamin B5 — essential nutrient for skin repair
72h
Sustained hydration with consistent use
96%
Of users reported smoother, softer skin
0%
Oil content — ideal for all skin types

Key Ingredients & What Each One Does

Hyaluronic Acid

Multi-weight · Comprehensive Hydration

Multi-molecular-weight hyaluronic acid provides hydration at every level: high-weight HA forms a moisture-retaining film on the skin surface, medium-weight HA plumps the mid-epidermis, and low-weight HA penetrates deeper to hydrate from within. This multi-level approach ensures the skin is hydrated thoroughly, not just superficially.

Vitamin B5 (Panthenol)

Pro-Vitamin · Repair & Moisture Regulation

Panthenol is a stable provitamin form of B5 that converts to pantothenic acid upon absorption. In the skin, it serves as a humectant (attracts moisture), an anti-inflammatory (soothes irritation and redness), and a wound-healing accelerator (stimulates fibroblast proliferation and epithelial cell migration). It also strengthens the skin's barrier function by supporting the production of barrier lipids.

Glycerin

Plant-Derived · Surface Hydration

A proven, gentle humectant that draws water from the environment and deeper skin layers to the surface, keeping the outermost layer of skin hydrated and supple. Glycerin also helps reinforce the skin's natural moisture barrier and improves the penetration of other active ingredients. Its lightweight, non-greasy feel makes it ideal for the gel formulation.

How to Use

01

Cleanse

Start with clean skin. Apply Hydrating B5 Gel to damp skin for maximum efficacy — the hyaluronic acid and glycerin immediately bind to surface moisture, locking it in.

02

Apply Gel

Dispense 3–5 drops of the gel onto fingertips. Spread evenly across the face, neck, and chest. The lightweight texture absorbs in seconds without any sticky or greasy residue.

03

Layer Actives

Use Hydrating B5 Gel as a hydration base before other serums and treatments. It creates a moisture-rich environment that enhances the absorption and efficacy of subsequent products.

04

Moisturize & Protect

Follow with your daily moisturizer to seal in the hydration. In the AM, finish with SPF 30+. Use twice daily — morning and evening — for optimal moisture replenishment.

Suitable Skin Types

Hydrating B5 Gel is truly universal — its oil-free, fragrance-free, lightweight formula is suitable for every skin type. It's particularly valuable for oily and acne-prone skin that needs hydration without heaviness, and for sensitive or post-procedure skin that requires gentle, soothing moisture.

Normal SkinDry SkinCombination SkinOily SkinSensitive SkinAcne-Prone Skin

Skin Concerns It Addresses

By addressing dehydration — the root cause of many visible skin issues — Hydrating B5 Gel helps improve fine lines, dullness, rough texture, and sensitivity. It's also an excellent support product for skin recovering from professional treatments or experiencing irritation from active ingredients.

Dryness & DehydrationDullnessFine LinesRough TextureSensitivity & IrritationPost-Procedure Recovery

The Science Behind the Formula

Why this specific combination of ingredients produces results that no single ingredient can achieve alone.

Pantothenic Acid Metabolism

Vitamin B5 is converted to pantothenic acid in the skin, which is then incorporated into Coenzyme A (CoA) — a molecule essential for cellular energy production, lipid synthesis, and protein metabolism. CoA is required for the synthesis of ceramides and fatty acids that make up the skin's barrier lipids. By supporting CoA production, B5 indirectly strengthens barrier function at the metabolic level.

Humectant Synergy

Hydrating B5 Gel combines three complementary humectants that work through different mechanisms: hyaluronic acid binds water through hydrogen bonding in the extracellular matrix, glycerin draws moisture to the skin surface, and panthenol attracts water while also modulating the skin's own moisture-regulation pathways. Together, they create a more complete hydration system than any single humectant alone.

Wound Healing Acceleration

Panthenol has been shown in clinical studies to accelerate epithelial cell migration and fibroblast proliferation — the two key processes in wound healing. This makes Hydrating B5 Gel particularly valuable for post-procedure skin, skin recovering from irritation caused by retinoids or exfoliants, and any situation where the skin's surface needs to repair and renew faster.

Frequently Asked Questions

Everything you need to know — answered directly and in detail.

Hydrating B5 Gel delivers three key benefits:

  • Deep hydration: Multi-weight hyaluronic acid + glycerin provide immediate and sustained moisture at every skin level.
  • Repair & soothing: Vitamin B5 accelerates skin repair, reduces irritation, and supports barrier function.
  • Smooth base: Creates an ideal moisture-rich foundation for serums, moisturizers, and makeup.

Yes — it's one of the best hydrators for oily skin. The formula is 100% oil-free with a lightweight gel texture that absorbs in seconds. Oily skin still needs hydration, and using Hydrating B5 Gel can actually help reduce excess oil production by signaling to the skin that it's adequately moisturized.

Yes — Hydrating B5 Gel is designed to complement active ingredients:

  • Under vitamin C: Apply B5 first as a hydrating base, then vitamin C serum on top.
  • With retinol: Apply B5 before or after retinol to buffer dryness and irritation.
  • Post-exfoliation: Apply B5 after AHA/BHA to soothe and rehydrate.

Its neutral pH and gentle formula make it compatible with virtually every active ingredient.

Hydrating B5 Gel is a hydrating serum, not a moisturizer. It delivers moisture (water + humectants) to the skin but doesn't contain the occlusive oils and emollients that moisturizers use to seal moisture in. For best results, always follow B5 Gel with a moisturizer to lock in the hydration. Think of it as the water layer, and your moisturizer as the seal.

Absolutely — Hydrating B5 Gel is one of the gentlest hydrating products available. It's fragrance-free, oil-free, and the Vitamin B5 actively soothes irritation and accelerates healing. Dermatologists frequently recommend it after:

  • Laser treatments
  • Chemical peels
  • Microneedling
  • Retinoid-induced dryness

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